MARTINSRIED, Germany, May 14, 2024 / Biotech Newswire / -- NEOsphere Biotechnologies GmbH, a German biotechnology company pioneering high-throughput proteomics to systematically build broad and unique portfolios of novel degrader targets at scale, today announced a collaboration with Kymera Therapeutics, Inc. (NASDAQ: KYMR) focused on unlocking undrugged or poorly drugged disease-causing protein targets that can be only or best addressed by Targeted Protein Degradation.
Under the agreement, NEOsphere Biotechnologies will utilize its target- and E3-agnostic platform to screen molecular glue compounds on a proteome-wide level and in a native context. Identified target candidates will be mechanistically validated by global ubiquitinomics, providing unparalleled insights to support Kymera’s robust drug discovery engine. NEOsphere Biotechnologies will receive an upfront payment and is eligible to success-based milestone payments.
“We are thrilled to collaborate with Kymera, a global leader in developing highly innovative degrader medicines. This partnership validates the unique potential of NEOsphere Biotechnologies’ platform to systematically explore the target space for molecular glues,” said Prof. Henrik Daub, CSO, and founder of NEOsphere Biotechnologies. “NEOsphere Biotechnologies and Kymera share a strong commitment to innovation and to advance degrader discovery to the next level. By combining Kymera's exceptional drug discovery capabilities with our ability to swiftly identify and proteomically validate novel targets, even for entire compound libraries, we aim to create valuable opportunities to target previously undruggable disease-causing proteins.”
Molecular glue degraders harness the cellular ubiquitin-proteasome system to selectively eliminate disease-causing proteins that are inaccessible with existing technologies, making them a promising therapeutic approach to address a variety of diseases in areas of high unmet need. NEOsphere Biotechnologies’ innovative technology identifies molecular glue targets at a speed that enables immediate compound optimization during ongoing screening. This presents a unique opportunity to significantly expand degrader target portfolios and to unlock the full potential of molecular glues.
About NEOsphere Biotechnologies GmbH
NEOsphere Biotechnologies is a leader in proteomics for targeted protein degradation drug discovery. Its unique target and E3 ligase-agnostic deep proteomic screening platform combines world-class mass spectrometry with expert data analysis to advance and characterize all types of protein degraders and stabilizers in native cells and to identify molecules that act through new E3 ligases and novel TPD mechanisms. This systematic approach creates broad pipelines of novel, high-value degrader targets at scale and advances its partners’ TPD drug discovery programs at all stages. NEOsphere Biotechnologies’ global ubiquitinomics platform rapidly mechanistically validates target candidates and confirms degrader induced modification to an unparalleled depth. Automated processes and exceptional high-throughput capabilities ensure maximum proteome coverage, accuracy, precision and data completeness, with short turnaround times compatible with drug optimization cycles. NEOsphere Biotechnologies’ intuitive and user-friendly data analysis applications visualize even large proteomics datasets for immediate access, enabling informed decisions in drug discovery, SAR optimization, target identification, and library expansion. For more information, please visit www.neospherebiotech.com or follow us on LinkedIn.
About Kymera Therapeutics
Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on delivering oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Kymera is also progressing degrader oncology programs that target undrugged or poorly drugged proteins to create new ways to fight cancer. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit https://www.kymeratx.com or follow us on X (previously Twitter) or LinkedIn.
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Keywords: Proteasome Endopeptidase Complex; Proteolysis; Proteome; Proteomics; Ubiquitin-Protein Ligases; Deubiquitinating Enzymes; Drug Discovery; Mass Spectrometry; Biotechnology; Data Analysis; Ubiquitins; Germany; NEOsphere Biotechnologies; Kymera Therapeutics; Molecular Glue Target Discovery; Proteomics; Targeted Protein Degradation; Collaboration; Platform; Ubiquitinomics; Drug discovery; Prof. Henrik Daub; Degrader medicines; Compound optimization; Cellular ubiquitin-proteasome system; Oral small molecule degraders; Undrugged proteins; Drug discovery programs
Source: Biotech Newswire